Description
Esomeprazole is in a group of drugs called proton pump inhibitors. Esomeprazole decreases the amount of acid produced in the stomach. Esomeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Esomeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).Esomeprazole may also be given to prevent gastric ulcer caused by infection with helicobacter pylori (H. pylori), or by the use of non steroidal anti-inflammatory drugs (NSAIDs).
Dosage
1 tablets once a day
Indications for use
Some of the conditions, esomeprazole may be prescribed for include:
• Dyspepsia
• Peptic ulcer
• Gastroesophageal reflux disorder
• Zollinger-Ellison syndrome
SIDE EFFECTS
Headache, diarrhea, abdominal pain, nausea, flatulence, constipation, dry mouth, dizziness, vertigo, Rare: rash, allergic reactions, hypomagnesemia, possible C. difficile-associated diarrhea.
Drug interactions
Esomeprazole is a competitive inhibitor of the enzyme CYP2C19, and may therefore interact with drugs that depend on it for metabolism, such as diazepam and warfarin, the concentrations of these drugs may increase if they are used concomitantly with esomeprazole. Conversely, clopidogrel is an inactive prodrug that partially depends on CYP2C19 for conversion to its active form, inhibition of CYP2C19 blocks the activation of clopidogrel, thus reducing its effects. Drugs that depend on stomach pH for absorption may interact with omeprazole, drugs that depend on an acidic environment will be poorly absorbed, whereas drugs that are broken down in acidic environments will be absorbed to a greater extent than normal.
